15: Heterocyclic Chemistry, and Some Biological Overtones (1964)


  • Adrien Albert Department of Medical Chemistry, John Curtin School of Medical Research, Australian National University


Liversidge Research Lecture, delivered before the Royal Society of New South Wales, June 9th, 1964. Reproduced by permission of the Royal Society of New South Wales from J. Proc. Roy. Soc. N.S.W., 1964-5, 98, 11-22.

"Because my deepest interest ever since school days, was to find out how drugs exerted their curative action, I studied biology alongside chemistry all through my undergraduate course. To-night I propose to describe some of the highlights of the research in which I became involved after completing my Ph.D. work in London and returning to Australia in 1937."

"In my thesis work, under the supervision of W. H. Linnell, I had synthesized a number of new polyaminoacridines but the reason why only some of them were antibacterial quite eluded us. It was later, while I was working in the Department of Organic Chemistry in the University of Sydney, that I resolved to simplify the problem by examining the monoaminoacridines."

Author Biography

Adrien Albert, Department of Medical Chemistry, John Curtin School of Medical Research, Australian National University


Though earlier in his career a registered pharmacist, as Foundation Professor and Head of the Medical Chemistry Department of the Australian National University, Adrien Albert’s research focused on nitrogen hetereocycles. Though he worked at the Wellcome Research Institute in London for two years (1947–1949), it was at ANU that he spent the majority of his career. Albert’s final monograph ‘Xenobiosis’ was awarded the Archibald Ollé prize in 1987.


For additional biographical information, photographic permissions, references and a list of honours, awards and publications, please see pages 2–4 of the transcript.


Albert, A., 1944. Med. J. Aust., i, 245.

Albert, A., 1955. J. Chem. Soc., 2690.

Albert, A., 1956. Nature, 177, 525; 178, 1672.

Albert, A., 1957. Biochem. J., 65, 124.

Albert, A., 1959. "Heterocyclic Chemistry." London: Athlone Press.

Albert, A., 1963. "Ionization Constants ", in "Physical Methods in Heterocyclic Chemistry" ed. A. Katritzky. New York: Academic Press.

Albert, A., and Armarego, W.L.F., 1963. J. Chem. Soc., 4237.

Albert, A., and Armarego, W.L.F., 1964. Advances in Heterocyclic Chemistry (ed. A.R. Katritzky), 4, 1.

Albert, A., Armarego, W.L.F., and Spinner, E., 1961. J. Chem. Soc. pp. 2689, 5267.

Albert, A., and Barlin, G.B., 1959. J. Chem. Soc., 2384 (cf. ibid., idem., 1962, 3129).

Albert, A., and Barlin, G.B., 1963. J. Chem. Soc., pp. 5156, 5737.

Albert, A., Brown, D.J., and Cheeseman, G.W.H., 1952. J. Chem. Soc., pp. 1620, 4219.

Albert, A., Gibson M.I., and Rubbo, S.D., 1953. Brit. J. exper. Path., 34, 119.

Albert, A., and Goldacre, R.J., 1943. J. Chem. Soc., 454.

Albert, A., Goldacre, R.J., and Phillips, J.N., 1948. J. Chem. Soc., 2240.

Albert, A., Hampton A., Selbie, F.R.,and Simon, R.D., 1954. Brit. J. exper. Path., 35, 75.

Albert, A., and Phillips, J.N., 1956. J. Chem. Soc., 1294.

Albert, A., and Rees C.W., 1956. Nature, 177, 433.

Albert, A., Rees, C.W., and Tomlinson, A.J.H., 1956. Brit. J. exper. Path., 37, 500.

Albert, A., Rubbo, S.D., and Burvill, M.I., 1949. Brit. J. exper. Path., 30, 159.

Albert, A., Rubbo, S.D., and Goldacre, R.J., 1941. Nature, 147, 332.

Albert, A., Rubbo, S.D., Goldacre, R.J., and Balfour, B.G., 1947. Brit. J. exper. Path., 28, 69.

Albert, A., Rubbo, S.D., Goldacre, R.J., Davey. M.E., and Stone, J.D., 1945. Brit. J. exper. Path., 26, 160.

Albert, A., and Serjeant, E.P., 1962. " Ionization Constants of Acids and Bases.". London: Methuen.

Albert, A., and Serjeant, E.P., 1964. J. Chem. Soc., 3357.

Anderson, B., and Swaby, R., 1951. Austral. J. Sci. Research, B4, 275.

Angier, R., Boothe, J., Hutchings, B., Mowat, J., Semb, J., Stokstad, E., Subbarow, Y., Waller, C., Cosulich, D., Fahrenbach, M., Hultquist, M., Kuh, E., Northey, E., Seeger, D., Sickels, J., and Smith, J., 1946. Science, 103, 667.

Angyal, S.J., and Angyal, C.L., 1952. J. Chem. Soc., 1461.

Armarego, W.L F., 1961. J. Chem. Soc., 2697.

Block, S., 1956. J. Agr. Food Chem., 4, 1042.

Brown, D.J., and Mason, S.F., 1956. J. Chem. Soc., 3443.

David, T.W.Edgeworth, 1931. J. Chem. Soc., 1039.

Gore, P., and Phillips, J. N., 1949. Nature, 163, 690.

Hopkins, F.G., 1895. Phil. Trans. Roy. Soc., B, 186, 661.

Lerman, L., 1963. Proc. Nat. Acad. Sci., Wash., 49, 94.

Nordbring-Hertz E., 1955. Physiol. Plantarum, 8, 691.

Perrin, D.D., 1962. J. Chem. Soc., 645.

Perrin, D.D., 1963. J. Chem. Soc., 2648.

Perrin, D.D., 1964. Advances in Heterocyclic Chemistry (ed. A.R. Katritzky), 4, 43.

Purrmann, R., 1940. Liebigs Ann. Chem., 544, 182 ; 546, 98.

Sijpesteijn, A., and Janssen, M., 1959. Antonie van Leeuwenhoek, 25, 422.

Stearn, A.E., and Stearn, E.W., 1924. J. Bact., 9, 491.

Vermast, P.G., 1921. Biochem. Z., 125, 106.

Williamson, J., 1959. Brit. J. Pharmacol. Chemother., 14, 443.

Portrait of Adrien Albert.